TRANSLATIONAL PHYSIOLOGY Evidence for increased postprandial distal nephron calcium delivery in hypercalciuric stone-forming patients
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چکیده
Elaine M. Worcester, Fredric L. Coe, Andrew P. Evan, Kristin J. Bergsland, Joan H. Parks, Lynn R. Willis, Daniel L. Clark, and Daniel L. Gillen Department of Medicine, University of Chicago School of Medicine, Chicago, Illinois; Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana; and Department of Statistics, University of California, Irvine, California
منابع مشابه
Evidence for increased postprandial distal nephron calcium delivery in hypercalciuric stone-forming patients.
A main mechanism of idiopathic hypercalciuria (IH) in calcium stone-forming patients (IHSF) is postprandial reduction of renal tubule calcium reabsorption that cannot be explained by selective reduction of serum parathyroid hormone levels; the nephron site(s) responsible are not as yet defined. Using fourteen 1-h measurements of the clearances of sodium, calcium, and endogenous lithium during a...
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The most common metabolic abnormality found in calcium (Ca) kidney stone formers is idiopathic hypercalciuria (IH). Using endogenous lithium (Li) clearance, we previously showed that in IH, there is decreased proximal tubule sodium absorption, and increased delivery of Ca into the distal nephron. Distal Ca reabsorption may facilitate the formation of Randall's plaque (RP) by washdown of excess ...
متن کاملIntestinal Calcium Absorption among Hypercalciuric Patients with or without Calcium Kidney Stones.
BACKGROUND AND OBJECTIVES Idiopathic hypercalciuria is a frequent defect in calcium kidney stone formers that is associated with high intestinal calcium absorption and osteopenia. Characteristics distinguishing hypercalciuric stone formers from hypercalciuric patients without kidney stone history (HNSFs) are unknown and were explored in our study. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS...
متن کاملSignificance of the calcium to creatinine concentration ratio of a single-voided urine specimen in patients with hypercalciuric urolithiasis.
Thirty-six patients with recurrent calcium oxalate nephrolithiasis were selected from the stone clinic. Fourteen were normocalcemic and had normal daily urinary calcium excretion. Among 22 patients with idiopathic hypercalciuria, 10 received thiazide diuretics for the prevention of new stone formation. Single-voided urine samples were collected at the outpatient clinic and 24-hour urine at the ...
متن کاملA Pilot Study of the Effect of Sodium Thiosulfate on Urinary Lithogenicity and Associated Metabolic Acid Load in Non-Stone Formers and Stone Formers with Hypercalciuria
BACKGROUND AND OBJECTIVES Sodium thiosulfate (STS) reduced calcium stone formation in both humans and genetic hypercalciuric stone forming (GHS) rats. We sought to measure urine chemistry changes resulting from STS administration in people. DESIGN SETTING PARTICIPANTS MEASUREMENTS: STS was given to healthy and hypercalciuric stone forming adults. Five normal non-stone forming adults (mean age 3...
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تاریخ انتشار 2008